4-(4-Chlorophenethyl)piperazin-2-one → HCID 123402311, 화합물

HRID 474960노트

반응식

HRID 474960 반응식
Br[C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[CH2:16][N:15]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:14][CH2:13][CH2:12][C:7]=3[N:8]([CH3:11])[C:9]=2[CH:10]=1.[Cl:24][C:25]1[CH:39]=[CH:38][C:28]([CH2:29][CH2:30][N:31]2[CH2:36][CH2:35][NH:34][C:33](=[O:37])[CH2:32]2)=[CH:27][CH:26]=1>>[Cl:24][C:25]1[CH:26]=[CH:27][C:28]([CH2:29][CH2:30][N:31]2[CH2:36][CH2:35][N:34]([C:2]3[CH:3]=[CH:4][C:5]4[C:6]5[CH2:16][N:15]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:14][CH2:13][CH2:12][C:7]=5[N:8]([CH3:11])[C:9]=4[CH:10]=3)[C:33](=[O:37])[CH2:32]2)=[CH:38][CH:39]=1

참가 물질

3

반응물 2

HCID 580922294-(4-Chlorophenethyl)piperazin-2-oneHCID 66874851tert-Butyl 8-bromo-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate

생성물 1

HCID 123402311HCID 123402311, 화합물수율 70.5%

실험 절차

tert-Butyl 8-bromo-6-methyl-3,4,5,6-tetrahydroazepino[4,3-b]indole-2(1H)-carboxylate (250 mg, 0.66 mmol) and 4-(4-chlorophenethyl)piperazin-2-one (157 mg, 0.66 mmol) were reacted following the procedure for Example 53 (step b) to provide the title compound (250 mg, 70%) as a colorless oil: ESI MS m/z 537 [M+H]+.

출처 및 근거

ORD 기록
ord-98c3716962434ccbbce011c0356af47d
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637501B2

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