trans-Crotonyl chloride → HCID 22172724, 화합물

HRID 47503

반응식

HRID 47503 반응식
[C:1](Cl)(=[O:5])/[CH:2]=[CH:3]/[CH3:4].[NH2:7][C:8]1[C:17]2[N:18]=[C:19]([CH2:24][CH2:25][CH2:26][CH3:27])[N:20]([CH2:21][CH2:22][NH2:23])[C:16]=2[C:15]2[N:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:9]=1>>[NH2:7][C:8]1[C:17]2[N:18]=[C:19]([CH2:24][CH2:25][CH2:26][CH3:27])[N:20]([CH2:21][CH2:22][NH:23][C:1](=[O:5])/[CH:2]=[CH:3]/[CH3:4])[C:16]=2[C:15]2[N:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:9]=1

참가 물질

3

반응물 2

HCID 643131trans-Crotonyl chlorideHCID 219460272-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethaneamine

생성물 1

HCID 22172724HCID 22172724, 화합물수율 81.1%

실험 절차

Using the general method of Example 92, crotonyl chloride (68 μL, 0.7 mmol) was reacted with 2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethaneamine (0.2 g, 0.7 mmol) to provide 0.2 g of N1-[2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethyl]-(E)-2-butenamide as a white powder, m.p. 198-200° C. Analysis: Calculated for C19H24N6O: %C, 64.75; %H, 6.86; %N, 23.85. Found: %C, 64.25; %H, 6.68; %N, 23.99. HRMS (EI) calcd for C19H24N6O (M+) 352.2011 found 352.1996

출처 및 근거

ORD 기록
ord-dfec2cbd71684deeb5a777d28289bb31
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699878B2

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