3,5-Di-tert-butyl-4-hydroxybenzoyl chloride → N1-[2-(4-amino-2-butyl 1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethyl]-3,5-di-(1,1-dimethylethyl)-4-hydroxybenzamide

참여 물질

역할	이름	HCID	투입량
반응물	3,5-Di-tert-butyl-4-hydroxybenzoyl chloride	HCID 3787187	—
반응물	2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethaneamine	HCID 21946027	—
생성물	N1-[2-(4-amino-2-butyl 1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethyl]-3,5-di-(1,1-dimethylethyl)-4-hydroxybenzamide	HCID 12112191	56.9%

반응 단계

Using the general method of Example 92, 3,5-di-(1,1 dimethylethyl)-4-hydroxybenzoyl chloride (0.47 g, 1.7 mmol) was reacted with 2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethaneamine (0.5 g, 1.7 mmol) to provide 0.5 g of N1-[2-(4-amino-2-butyl-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl)ethyl]-3,5-di-(1,1-dimethylethyl) -4-hydroxybenzamide as a white powder, m.p. 248-250° C. Analysis: Calculated for C30H40N6O2: %C, 69.74; %H, 7.80; %N, 16.27. Found: %C, 69.65%H, 7.69; %N, 16.42. HRMS (EI) calcd for C30H40N6O2 (M+) 516.3212 found 516.3226

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06699878B2
출처 데이터셋	uspto-grants-2004_03
ORD ID	ord-19bf6bf51d18408db2f50571ebc95467
출처 메모	uspto-grants-2004_03