Formic Acid → HCID 178419331, 화합물

반응식

[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[CH:6][CH:7]=1.[CH:10](O)=O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[NH:8][CH:10]=[N:9][C:4]=2[CH:3]=1

참가 물질

반응물 2

HCID 284Formic Acid

HCID 3235934-Bromobenzene-1,2-diamine

생성물 1

HCID 178419331HCID 178419331, 화합물수율 100%

반응 조건

온도: 100 °C

실험 절차

A mixture of 4-bromobenzene-1,2-diamine (4.0 g, 21.5 mmol) and formic acid (95%, 100 mL) was stirred at 100° C. overnight. The reaction mixture was cooled to RT and concentrated in vacuo to afford a dark oil. The crude oil was partitioned between EtOAc (500 mL) and NH3/H2O (50 mL). The EtOAc layer was separated and concentrated in vacuo to afford 4.5 g (100%) of 5-bromo-1H-benzo[d]imidazole (78) as brown solid: MS (ESI) m/z=197.0 (M+1).

후처리

temperatureThe reaction mixture was cooled to RT
concentrationconcentrated in vacuo
customto afford a dark oil
customThe crude oil was partitioned between EtOAc (500 mL) and NH3/H2O (50 mL)
customThe EtOAc layer was separated
concentrationconcentrated in vacuo

출처 및 근거

ORD 기록: ord-2cdb7cd6e94c4ed4b6a3107380ddf1cd
출처 데이터셋: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08637537B2

반응 노트

불러오는 중…