Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-methyl-1H-indole-5-carbonitrile → (1-methyl-1H-indol-5-yl)methylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-methyl-1H-indole-5-carbonitrile | HCID 11412513 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Ammonia | HCID 222 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (1-methyl-1H-indol-5-yl)methylamine | HCID 18525752 | 97.5% |
반응 단계
To a solution of 294 (800 mg, 5.12 mmol) in 7M ammonia in MeOH (50 mL) was added Raney Ni (2.0 g) and the reaction mixture was stirred vigorously under H2 (1 atm.) atmosphere at RT for 18 h. The reaction mixture was filtered through a pad of Celite® and concentrated in vacuo to afford 800 mg of (1-methyl-1H-indol-5-yl)methanamine (296) as yellow oil: MS (ESI) m/z=144.3 [M-NH2]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08637537B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-dd7b3e8fbf3d496f9f47619c07dbacbe |
| 출처 메모 | uspto-grants-2014_01 |