1-methyl-1H-indole-5-carbonitrile → (1-methyl-1H-indol-5-yl)methylamine

HRID 475294

반응식

HRID 475294 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]#[N:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3]1>N.CO.[Ni]>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([CH2:11][NH2:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3]1

참가 물질

5

반응물 1

HCID 114125131-methyl-1H-indole-5-carbonitrile

생성물 1

HCID 18525752(1-methyl-1H-indol-5-yl)methylamine수율 97.5%

시약·촉매·용매 3

HCID 935Nickel촉매HCID 222Ammonia용매HCID 887Methanol용매

실험 절차

To a solution of 294 (800 mg, 5.12 mmol) in 7M ammonia in MeOH (50 mL) was added Raney Ni (2.0 g) and the reaction mixture was stirred vigorously under H2 (1 atm.) atmosphere at RT for 18 h. The reaction mixture was filtered through a pad of Celite® and concentrated in vacuo to afford 800 mg of (1-methyl-1H-indol-5-yl)methanamine (296) as yellow oil: MS (ESI) m/z=144.3 [M-NH2]+.

후처리

  1. filtrationThe reaction mixture was filtered through a pad of Celite®
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-dd7b3e8fbf3d496f9f47619c07dbacbe
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637537B2

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