Urea → 6-Bromo-8-methoxyquinazolin-2(1H)-one

HRID 475317노트

반응식

HRID 475317 반응식
[NH2:1][C:2]1[C:9]([O:10][CH3:11])=[CH:8][C:7]([Br:12])=[CH:6][C:3]=1[CH:4]=O.[NH2:13][C:14](N)=[O:15]>O>[Br:12][C:7]1[CH:6]=[C:3]2[C:2](=[C:9]([O:10][CH3:11])[CH:8]=1)[NH:1][C:14](=[O:15])[N:13]=[CH:4]2

참가 물질

4

반응물 2

HCID 1176UreaHCID 153804452-Amino-5-bromo-3-methoxybenzaldehyde

생성물 1

HCID 534388076-Bromo-8-methoxyquinazolin-2(1H)-one

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
180 °C

실험 절차

2-amino-5-bromo-3-methoxybenzaldehyde (2.5 g, 10.87 mmol) is homogeneously mixed with urea and the mixture is heated to 180° C. The melt formed is kept at this temperature for 1 h. Then the reaction mixture is mixed with water, the precipitate formed is filtered off, dried and 6-bromo-8-methoxy-1H-quinazolin-2-one (HPLC-MS: tRet.=1.53 min MS(M+H)+=255/257; method FSUN) is obtained.

후처리

  1. customThe melt formed
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. customdried

출처 및 근거

ORD 기록
ord-d54da5bf201a470b93c70f92d8160d29
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637549B2

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