6-amino-3-bromo-2-fluorobenzonitrile → 6-Bromo-2-chloro-5-fluoroquinazoline

HRID 475321노트

반응식

HRID 475321 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10](OC)[CH:11]=1)[N:8]=[C:7]([Cl:14])[N:6]=[CH:5]2.NC1C=CC(Br)=C([F:25])C=1C#N>>[Br:1][C:2]1[C:3]([F:25])=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([Cl:14])[N:6]=[CH:5]2

참가 물질

3

반응물 2

HCID 27611996-amino-3-bromo-2-fluorobenzonitrileHCID 467382966-Bromo-2-chloro-8-methoxyquinazoline

생성물 1

HCID 574611366-Bromo-2-chloro-5-fluoroquinazoline

실험 절차

6-bromo-2-chloro-5-fluoro-quinazoline is prepared analogously to WO 2007/117607 or to the above-mentioned synthesis of 6-bromo-2-chloro-8-methoxy-quinazoline starting from 2-amino-5-bromo-6-fluoro-benzonitrile.

출처 및 근거

ORD 기록
ord-29843d3dc15349dc9dfb4e5790aa0626
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637549B2

반응 노트

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