Isopropylamine → 1-(2-Chloro-4-isopropylaminopyrimidin-5-yl)-ethanone

HRID 475322노트

반응식

HRID 475322 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([C:9](=[O:11])[CH3:10])=[CH:4][N:3]=1.C(=O)([O-])O.[Na+].[CH:17]([NH2:20])([CH3:19])[CH3:18].C1CCCCC1>C1COCC1>[Cl:1][C:2]1[N:7]=[C:6]([NH:20][CH:17]([CH3:19])[CH3:18])[C:5]([C:9](=[O:11])[CH3:10])=[CH:4][N:3]=1

참가 물질

6

반응물 4

HCID 6363IsopropylamineHCID 8078CyclohexaneHCID 516892Sodium BicarbonateHCID 212747081-(2,4-Dichloropyrimidin-5-yl)ethan-1-one

생성물 1

HCID 574611371-(2-Chloro-4-isopropylaminopyrimidin-5-yl)-ethanone

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1-(2,4-dichloro-pyrimidin-5-yl)-ethanone (10 g, 0.052 mol), sodium hydrogen carbonate (19.35 g, 0.058 mol) and isopropylamine (5 mL, 0.058 mol) are taken up in 35 mL THF and 200 mL cyclohexane and stirred for 2 h at 20° C. The reaction solution is filtered through silica gel, the solvent is eliminated in vacuo and 1-(2-chloro-4-isopropylaminopyrimidin-5-yl)-ethanone (HPLC-MS: tRet.=1.73 min, MS(M+H)+=214/216; method FECB3) is obtained.

후처리

  1. filtrationThe reaction solution is filtered through silica gel

출처 및 근거

ORD 기록
ord-68033b788dce4a37b212e189f222e7ac
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637549B2

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