Urea → HCID 178517174, 화합물
반응식
[NH2:1][C:2]1[C:3]([CH:9]=O)=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.[NH2:11][C:12](N)=[O:13]>O>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]2[C:3]([N:4]=1)=[CH:9][NH:11][C:12](=[O:13])[N:1]=2참가 물질
4
반응 조건
- 온도
- 180 °C
실험 절차
3-amino-6-chloro-pyridine-2-carbaldehyde (3.2 g, 13.0 mmol) is mixed thoroughly with urea (7.8 g, 130 mmol) and heated to 180° C. in the preheated oil bath for 3 h. Then the reaction mixture is suspended in H2O, the precipitate is filtered off and 6-chloro-3H-pyrido[3,2-d]pyrimidin-2-one is obtained.
후처리
- filtrationthe precipitate is filtered off
출처 및 근거
- ORD 기록
- ord-807bfca2af4c47ee97433cf8fbcbe68d
- 출처 데이터셋
- uspto-grants-2014_01
- 특허 번호
- US08637549B2
반응 노트
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