Sulfuric acid magnesium salt (1:1) → HCID 178505794, 화합물

HRID 475431노트

반응식

HRID 475431 반응식
[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[C:6]([C:9]3[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=3[CH:11]=O)=[N:7][O:8][C:4]=2[CH:3]=1.[F:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]([C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=2)[NH2:27])=[CH:22][CH:21]=1.S([O-])([O-])(=O)=O.[Mg+2]>ClCCl>[Br:1][C:2]1[CH:18]=[CH:17][C:5]2[C:6]([C:9]3[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=3/[CH:11]=[N:27]/[CH:26]([C:23]3[CH:24]=[CH:25][C:20]([F:19])=[CH:21][CH:22]=3)[C:28]3[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=3)=[N:7][O:8][C:4]=2[CH:3]=1

참가 물질

5

반응물 3

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 109550394-Fluoro-alpha-(4-fluorophenyl)benzenemethanamineHCID 866759952-(6-Bromobenzo[d]isoxazol-3-yl)benzaldehyde2회

생성물 1

HCID 178505794HCID 178505794, 화합물수율 72%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of 2-(6-bromobenzo[d]isoxazol-3-yl)benzaldehyde (compound 7) (2 g) in dichloromethane (33 mL) was added bis(4-fluorophenyl)methanamine (1.74 g) and anhydrous magnesium sulfate and stirred under nitrogen at room temperature for 18 h. Filtration and evaporation of the filtrate and crystallisation from dichloromethane-methanol gave the title compound (2.4 g).

후처리

  1. filtrationFiltration and evaporation of the filtrate and crystallisation from dichloromethane-methanol

출처 및 근거

ORD 기록
ord-4015796ac46d441698388cef6c323ce6
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637551B2

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