Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
o-Fluorobenzaldehyde → (7bR,11aS)-N-(2-fluorobenzyl)-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indol-6-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | o-Fluorobenzaldehyde | HCID 67970 | — |
| 반응물 | Tert-butyl (7br,11as)-6-amino-1,2,7b,10,11,11a-hexahydro-4h-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8h)carboxylate | HCID 86586438 | — |
| 생성물 | (7bR,11aS)-N-(2-fluorobenzyl)-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indol-6-amine | HCID 60071868 | — |
반응 단계
Using 2-fluorobenzaldehyde and following the procedures described in EXAMPLE 126, tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate from EXAMPLE 56, Part B was converted into the title compound of EXAMPLE 134. LRMS (ES)+: 354.3 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06699852B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-496e39e6974344f684fe280d500bdf80 |
| 출처 메모 | uspto-grants-2004_03 |