(Bromomethyl)cyclobutane → (7bR,11aS)-9-(cyclobutylmethyl)-N-[2-fluoro-3-(trifluoromethyl)phenyl]-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indol-6-amine

HRID 47570

반응식

HRID 47570 반응식
Br[CH2:2][CH:3]1[CH2:6][CH2:5][CH2:4]1.[F:7][C:8]1[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:11]=[CH:10][C:9]=1[NH:18][C:19]1[CH:20]=[C:21]2[C:25]3=[C:26]([CH2:28][O:29][CH2:30][CH2:31][N:24]3[C@H:23]3[CH2:32][CH2:33][NH:34][CH2:35][C@@H:22]23)[CH:27]=1>>[CH:3]1([CH2:2][N:34]2[CH2:33][CH2:32][C@@H:23]3[N:24]4[CH2:31][CH2:30][O:29][CH2:28][C:26]5[CH:27]=[C:19]([NH:18][C:9]6[CH:10]=[CH:11][CH:12]=[C:13]([C:14]([F:15])([F:16])[F:17])[C:8]=6[F:7])[CH:20]=[C:21]([C:25]4=5)[C@@H:22]3[CH2:35]2)[CH2:6][CH2:5][CH2:4]1

참가 물질

3

반응물 2

HCID 2734658(Bromomethyl)cyclobutaneHCID 60071829(7bR,11aS)-N-[2-fluoro-3-(trifluoromethyl)phenyl]-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indol-6-amine

생성물 1

HCID 20627673(7bR,11aS)-9-(cyclobutylmethyl)-N-[2-fluoro-3-(trifluoromethyl)phenyl]-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indol-6-amine

실험 절차

Using bromomethylcyclobutane and following the procedures described in EXAMPLE 144, (7bR,11aS)-N-[2-fluoro-3-(trifluoromethyl)phenyl]-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indol-6-amine free base from EXAMPLE 95 was converted into the title compound of EXAMPLE 145. 1H NMR(CDCl3) δ: 7.15 (dd, 1H, J=7.8, 6.8 Hz), 7.05-6.95 (m, 2H), 6.89 (d, 1H, J=1.9 Hz), 6.77 (d, 1H, J=2.0 Hz), 5.73 (d, 1H, J=3.0 Hz), 4.63 (ABq, 2H, JAB=14.1 Hz), 4.24 (app d, 1H, J=12.8 Hz), 3.75 (app t, 1H), 3.50-3.30 (m, 2H), 3.25 (dd, 1H, J=13.1, 2.8 Hz), 2.95-2.30 (overlapping multiplets, 7H), 2.15-1.65 (overlapping multiplets, 9H). LRMS (ES)+: 476.4 (M+H)+.

출처 및 근거

ORD 기록
ord-7c349c641ca44e8895a885b63a25b931
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699852B2

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