1-Cyclopropyl-2-methoxyethan-1-amine → 2-chloro-N-(1-cyclopropyl-2-methoxyethyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

HRID 475768노트

반응식

HRID 475768 반응식
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[CH2:10][CH2:9][CH:8]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[C:6]=2[N:7]=1.[CH:19]1([CH:22]([NH2:26])[CH2:23][O:24][CH3:25])[CH2:21][CH2:20]1>>[Cl:1][C:2]1[N:3]=[C:4]([NH:26][CH:22]([CH:19]2[CH2:21][CH2:20]2)[CH2:23][O:24][CH3:25])[C:5]2[CH2:10][CH2:9][CH:8]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[C:6]=2[N:7]=1

참가 물질

3

반응물 2

HCID 534149871-Cyclopropyl-2-methoxyethan-1-amineHCID 580754242,4-Dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[D]pyrimidine

생성물 1

HCID 580756552-chloro-N-(1-cyclopropyl-2-methoxyethyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine

실험 절차

2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine (Preparation H) was reacted as described in Preparation Hr with 1-cyclopropyl-2-methoxyethanamine to afford 2-chloro-N-(1-cyclopropyl-2-methoxyethyl)-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine (Preparation Hw) as a mixture of 4 diasteriomers. LC-MS (M+H)+=362.1.

출처 및 근거

ORD 기록
ord-f180a71c70ef48b6a3fcd448edc4a4b2
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637525B2

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