Ammonia → 1-(2-Amino-3,5-dinitrophenyl)-2-propanol

HRID 4758

반응식

HRID 4758 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([N+:14]([O-:16])=[O:15])[C:7]2[O:11][CH:10]([CH3:12])[CH2:9][C:8]=2[CH:13]=1)([O-:3])=[O:2].[NH3:17].COCCO>O>[NH2:17][C:7]1[C:6]([N+:14]([O-:16])=[O:15])=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:13][C:8]=1[CH2:9][CH:10]([OH:11])[CH3:12]

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 80192-MethoxyethanolHCID 198363332-Methyl-5,7-dinitro-2,3-dihydro-1-benzofuran

생성물 1

HCID 198363271-(2-Amino-3,5-dinitrophenyl)-2-propanol

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

0.39 Mole (88 g) of 2,3-dihydro-5,7-dinitro-2-methylbenzofuran, prepared according to J.A.C.S. 80, p. 4711-4714 (1958), is suspended in 1.1 l of 20% strength ammonia solution and 600 ml of Methyl Cellosolve. After 18 hours' heating at 70° C., the reaction mixture is cooled. The precipitate formed is drained and, after being made into a paste in water until neutral and then dried under vacuum, is recrystallized from 170 ml of dioxane. After being dried under vacuum, 0.30 mole (72 g) of the expected product is obtained; it melts at 177° C.

후처리

  1. temperaturethe reaction mixture is cooled
  2. customThe precipitate formed
  3. customthen dried under vacuum
  4. customis recrystallized from 170 ml of dioxane
  5. customAfter being dried under vacuum

출처 및 근거

ORD 기록
ord-5155b74041e040c5848aa97537ebe3cb
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04727192

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