참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-Bromo-2-fluorotoluene | HCID 123527 | — |
| 반응물 | Methyl isonipecotate | HCID 424914 | — |
| 시약 | Sodium t-butoxide | HCID 23676156 | — |
| 촉매 | Binap, (A+-)- | HCID 634876 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Methyl N-(4-fluoro-3-methylphenyl)piperidine-4-carboxylate | HCID 59023366 | 0% |
반응 단계
In a 100 mL round-bottomed flask methyl piperidine-4-carboxylate (2.2 g, 15.36 mmol),4-bromo-1-fluoro-2-methylbenzene (1.954 mL, 15.36 mmol),Pd2(dba)3 (0.521 g, 0.57 mmol),BINAP (0.574 g, 0.92 mmol) and sodium tert-butoxide (4.43 g, 46.09 mmol) was taken in toluene (10 mL) under N2.The resulting reaction was stirred at 110 °C for 3 hrs. LCMS did not show product MS.Material was discrded.
출처 및 근거
| 출처 데이터셋 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-498c0c75d66a47609408cbfbddaef8e5 |
|---|
| 출처 메모 | 750 AstraZeneca ELN dataset |
|---|
