1-(4-Fluorophenyl)cyclopentanecarboxylic acid → [(7R)-7-({[1-(4-fluorophenyl)cyclopentyl]carbonyl}amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid

HRID 476232

반응식

HRID 476232 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:13]([OH:15])=O)[CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[NH2:16][C@H:17]1[CH2:36][N:21]2[C:22]3[C:27]([C:28]([CH2:29][C:30]([O:32]CCC)=[O:31])=[C:20]2[CH2:19][CH2:18]1)=[CH:26][CH:25]=[CH:24][CH:23]=3>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:13]([NH:16][C@H:17]3[CH2:36][N:21]4[C:22]5[C:27]([C:28]([CH2:29][C:30]([OH:32])=[O:31])=[C:20]4[CH2:19][CH2:18]3)=[CH:26][CH:25]=[CH:24][CH:23]=5)=[O:15])[CH2:9][CH2:10][CH2:11][CH2:12]2)=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 7361331-(4-Fluorophenyl)cyclopentanecarboxylic acidHCID 58349691(R)-propyl 2-(7-amino-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate

생성물 1

HCID 58349688[(7R)-7-({[1-(4-fluorophenyl)cyclopentyl]carbonyl}amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid

실험 절차

The title compound was prepared using analogous procedures described in Example 1 (Method A) from 1-(4-fluorophenyl)cyclopentanecarboxylic acid and propyl [(7R)-7-amino-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate. MS (+ESI) m/z: 435.

출처 및 근거

ORD 기록
ord-8f54914aab90450489e49da5ed3a4d79
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637671B2

연결된 노트

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