Benzene, 1-bromo-3,5-dimethyl- → 1,2-Bis(bis(3,5-dimethylphenyl)phosphino)benzene

HRID 476323

반응식

HRID 476323 반응식
[CH3:1][C:2]1[CH:3]=[C:4](Br)[CH:5]=[C:6]([CH3:8])[CH:7]=1.[Mg].[CH3:11][C:12]1[CH:13]=[C:14]([Mg]Br)[CH:15]=[C:16]([CH3:18])[CH:17]=1.Cl[P:22](Cl)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[P:29](Cl)Cl>C1COCC1>[CH3:1][C:2]1[CH:3]=[C:4]([P:22]([C:4]2[CH:5]=[C:6]([CH3:8])[CH:7]=[C:2]([CH3:1])[CH:3]=2)[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[P:29]([C:4]2[CH:5]=[C:6]([CH3:8])[CH:7]=[C:2]([CH3:1])[CH:3]=2)[C:14]2[CH:13]=[C:12]([CH3:11])[CH:17]=[C:16]([CH3:18])[CH:15]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1

참가 물질

6

반응물 4

HCID 136357Benzene, 1-bromo-3,5-dimethyl-HCID 33165621,2-Bis(dichlorophosphino)benzeneHCID 5462224MagnesiumHCID 178425074HCID 178425074, 화합물

생성물 1

HCID 183243201,2-Bis(bis(3,5-dimethylphenyl)phosphino)benzene

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

3,5-Dimethylbromobenzene (5.54 g, 29.93 mmol) was added dropwise to magnesium (1.07 g, 44.03 mmol) and THF (30 mL) in an argon atmosphere. The reaction mixture was cooled to ambient temperature and filtered, and the thus-obtained THF solution of 3,5-dimethylphenylmagnesium bromide, and 1,2-bis(dichlorophosphino)benzene (0.95 g, 3.39 mmol) were reacted as in Production Example 1. The reaction was allowed to proceed overnight at 60° C. After purification, the title compound was obtained as a white powder (1.45 g, yield 76%).

후처리

  1. filtrationfiltered
  2. customAfter purification

출처 및 근거

ORD 기록
ord-54025fffc9d94247b3250ce08c963bc2
출처 데이터셋
uspto-grants-2014_01
특허 번호
US08637710B2

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