Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclohexyl bromide → 1-Cyclohexyl-4-methoxybenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclohexyl bromide | HCID 7960 | — |
| 반응물 | Pyrazine | HCID 9261 | — |
| 반응물 | HCID 178491912 | HCID 178491912 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-Cyclohexyl-4-methoxybenzene | HCID 221526 | 96% |
반응 단계
Bromocyclohexane (81.8 mg, 0.5 mmol) and a THF solution (0.85 mL, 0.88 M, 0.75 mmol) of 4-methoxyphenylmagnesium bromide were used as starting materials, and reacted as in Entry 1. Conditions: The THF solution of 4-methoxyphenylmagnesium bromide was added dropwise at 25° C. over 20 minutes. 1H-NMR analysis was conducted using pyrazine (19.0 mg, 0.24 mmol) as an internal standard (yield 96%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08637710B2 |
| 출처 데이터셋 | uspto-grants-2014_01 |
| ORD ID | ord-70edcfce12f74e29852fa6f91783a422 |
| 출처 메모 | uspto-grants-2014_01 |