Potassium Carbonate → Ethyl (N-methyl-3-trifluoromethylbenzylsulfonamido)acetate

HRID 476519

반응식

HRID 476519 반응식
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[CH2:6][S:7](Cl)(=[O:9])=[O:8].[CH2:16]([O:18][C:19](=[O:23])[CH2:20][NH:21][CH3:22])[CH3:17].C(=O)([O-])[O-].[K+].[K+]>O>[CH3:22][N:21]([CH2:20][C:19]([O:18][CH2:16][CH3:17])=[O:23])[S:7]([CH2:6][C:5]1[CH:11]=[CH:12][CH:13]=[C:3]([C:2]([F:15])([F:14])[F:1])[CH:4]=1)(=[O:9])=[O:8]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 95849Glycine, N-methyl-, ethyl esterHCID 27946463-(Trifluoromethyl)phenylmethanesulfonyl chloride

생성물 1

HCID 15118078Ethyl (N-methyl-3-trifluoromethylbenzylsulfonamido)acetate

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

In this example, 22 g of 3-trifluoromethylbenzylsulfonyl chloride was added cautiously to a solution containing 27 g of the hydrochloride salt of sarcosine ethyl ester and 12 g of potassium carbonate in 90 ml of water at room temperature. The reaction mixture was heated to about 70° C. and maintained at this temperature for about four hours. The mixture was allowed to cool and then extracted with ethyl ether. The ethyl ether extract was dried over magnesium sulfate, filtered, and evaporated to dryness yielding 9.5 g of the title compound as an off-white solid.

후처리

  1. temperaturemaintained at this temperature for about four hours
  2. temperatureto cool
  3. extractionextracted with ethyl ether
  4. extractionThe ethyl ether extract
  5. dry with materialwas dried over magnesium sulfate
  6. filtrationfiltered
  7. customevaporated to dryness

출처 및 근거

ORD 기록
ord-83bc17cc94464749af416e1a13827d0e
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04885027

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