참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | (4-Nitrophenyl)acetic acid | HCID 4661 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 4-(Diethylamino)benzaldehyde | HCID 67114 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4'-Diethylamino-4-nitrostilbene | HCID 624657 | — |
반응 단계
A mixture of 5.00 g (28 mmol) of 4-diethylaminobenzaldehyde, 5.62 g (31 mmol) of 4-nitrophenylacetic acid, 2.40 g (28 mmol) of piperidine, and 100 mL of xylenes was heated with stirring at reflux for 20 hours with continuous removal of water using a Dean-Stark apparatus. The mixture turned dark red. Approximately half the xylenes was distilled, and the residue was cooled to 3 0° C. Red crystals separated which were collected and then recrystallized from isopropanol/pyridine. Yield: 4.05 g (48%), mp 179-181 (lit2 182°-182.5° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04886339 |
|---|
| 출처 데이터셋 | uspto-grants-1989_12 |
|---|
| ORD ID | ord-80647dae8203445495a8ed0ef8b2870e |
|---|
| 출처 메모 | uspto-grants-1989_12 |
|---|
