Morpholine → 2-(2-Hydroxyphenyl)-1-(4-morpholinyl)ethanone

HRID 476856

반응식

HRID 476856 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[O:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[CH2:9][C:8]1=[O:16]>C(O)C>[OH:7][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[CH2:9][C:8]([N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1)=[O:16]

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 683822(3H)-Benzofuranone

생성물 1

HCID 147733702-(2-Hydroxyphenyl)-1-(4-morpholinyl)ethanone수율 90.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

27.3 g of morpholine are added in a single portion to a solution of 30 g of 2,3-dihydro-2-benzofuranone in 100 ml of ethanol, and the medium is stirred for 1 hour. The solvent is evaporated off under vacuum, the residual gum is taken up in isopropyl ether in the hot state and the medium is allowed to return to room temperature. The crystallized product is filtered, washed with isopropyl ether and dried. 45 g of white crystallized product are obtained.

후처리

  1. customThe solvent is evaporated off under vacuum
  2. customto return to room temperature
  3. filtrationThe crystallized product is filtered
  4. washwashed with isopropyl ether
  5. customdried

출처 및 근거

ORD 기록
ord-37ebd319bdab4e1abd704dd7351dbe65
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886799

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