Chloroacetonitrile → HCID 19837048, 화합물

HRID 476876노트

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HRID 476876 반응식
[CH3:1][C:2]1[CH:3]=[C:4]2[C:11](=[CH:12][CH:13]=1)[C:7]([CH2:8][CH2:9][NH2:10])=[CH:6][NH:5]2.Cl[CH2:15][C:16]#[N:17]>O1CCCC1.C(Cl)Cl>[CH3:1][C:2]1[CH:3]=[C:4]2[C:11]([C:7]([CH2:8][CH2:9][NH:10][CH2:15][C:16]#[N:17])=[CH:6][NH:5]2)=[CH:12][CH:13]=1

참가 물질

5

반응물 2

HCID 7856ChloroacetonitrileHCID 1900062-(6-Methyl-1H-indol-3-yl)ethan-1-amine

생성물 1

HCID 19837048HCID 19837048, 화합물

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매

실험 절차

17 g of 6-methyltryptamine were dissolved at 40° C. under inert atmosphere in 500 ml of tetrahydrofuran, and the solution was allowed to return to ambient temperature. 14.6 ml of 1,5-diaza[5,4,0]undec-5-ene were added followed by 6.2 ml of chloroacetonitrile and stirring for 15 hours. The solvent was eliminated under reduced pressure and the residue was taken up in 250 ml of methylene chloride, washed with water, dried and concentrated to dryness. The 25 g of crude product was purified by chromatography on silica (eluent: methylene chloride-ethyl acetate 3-7) to obtain 13.2 g of the expected product melting at 92° C.

후처리

  1. customto return to ambient temperature
  2. washwashed with water
  3. customdried
  4. concentrationconcentrated to dryness
  5. customThe 25 g of crude product was purified by chromatography on silica (eluent: methylene chloride-ethyl acetate 3-7)

출처 및 근거

ORD 기록
ord-18c2620c8e904afd9387c033a505751a
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886802

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