Chloroacetonitrile → 2-[[2-(6-methoxy-1H-indol-3-yl)-ethyl]-amino]-acetonitrile

HRID 476878

반응식

HRID 476878 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:12](=[CH:13][CH:14]=1)[C:8]([CH2:9][CH2:10][NH2:11])=[CH:7][NH:6]2.[CH2:15]([N:17](CC)CC)[CH3:16].ClCC#N>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:12]([C:8]([CH2:9][CH2:10][NH:11][CH2:16][C:15]#[N:17])=[CH:7][NH:6]2)=[CH:13][CH:14]=1

참가 물질

5

반응물 3

HCID 7856ChloroacetonitrileHCID 8471TriethylamineHCID 176542-(2-Aminoethyl)-5-methoxyindole

생성물 1

HCID 198370192-[[2-(6-methoxy-1H-indol-3-yl)-ethyl]-amino]-acetonitrile

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

28.5 g of 6-methoxytryptamine were refluxed in 300 ml of tetrahydrofuran in the presence of 42 ml of triethylamine and 11.4 ml of chloroacetonitrile were added over 2 hours. The heating was continued for 1 hour and after allowing the temperature to return to the ambient, the precipitate was eliminated by filtration. The filtrate was concentrated to dryness under reduced pressure and the residue was taken up in ethyl acetate, washed with water, dried and the solvent was eliminated under reduced pressure to obtain 17.9 g of the expected product melting at approx. 80° C.

후처리

  1. additionwere added over 2 hours
  2. filtrationthe precipitate was eliminated by filtration
  3. concentrationThe filtrate was concentrated to dryness under reduced pressure
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-b6a94d5dd8734371acbf505ffefe1648
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886802

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