Tetrahydrofuran → Ethyl 4-[2-(1H-indol-3-yl)-ethyl]-3-oxo-1-(1-oxododecyl)-2-piperazine acetate

HRID 476882

반응식

HRID 476882 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][NH:15][CH:14]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:13]2=[O:24])=[CH:2]1.C(N(CC)CC)C.[CH2:32](Cl)[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43].[O:45]1CCCC1>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][N:15]([C:32](=[O:45])[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43])[CH:14]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:13]2=[O:24])=[CH:2]1

참가 물질

5

반응물 4

HCID 8028TetrahydrofuranHCID 81921-ChlorododecaneHCID 8471TriethylamineHCID 14257258Ethyl 4-[2-(1H-indol-3-yl)-ethyl]-3-oxo-2-piperazine acetate

생성물 1

HCID 70378265Ethyl 4-[2-(1H-indol-3-yl)-ethyl]-3-oxo-1-(1-oxododecyl)-2-piperazine acetate

실험 절차

2.14 g of the product of Step C of Example 1 were dissolved in a mixture containing 1.4 ml of triethylamine and 25 ml of tetrahydrofuran. 1.5 ml of lauryl chloride were added dropwise and after stirring for 30 minutes, the precipitate was filtered off. The filtrate was concentrated to dryness and the residue was taken up in methylene chloride, washed with water and dried. The solvent was eliminated under reduced pressure at 50° C. to obtain 3.2 g of the expected product.

후처리

  1. filtrationthe precipitate was filtered off
  2. concentrationThe filtrate was concentrated to dryness
  3. washwashed with water
  4. customdried
  5. customwas eliminated under reduced pressure at 50° C.

출처 및 근거

ORD 기록
ord-bd0dc14117b6432784458830487d75c4
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886802

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