Methylamine → HCID 15594865, 화합물

HRID 476915노트

반응식

HRID 476915 반응식
[C:1]([C:3]1[C:4](=[O:17])[N:5]([CH3:16])[C:6](=[O:15])[N:7]([CH3:14])[C:8]=1[N:9]=[CH:10][N:11](C)C)#[N:2].[CH3:18]N>CO>[CH3:18][NH:2][C:1]1[N:11]=[CH:10][N:9]=[C:8]2[N:7]([CH3:14])[C:6](=[O:15])[N:5]([CH3:16])[C:4](=[O:17])[C:3]=12

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 53948848HCID 53948848, 화합물

생성물 1

HCID 15594865HCID 15594865, 화합물수율 85%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

0.47 g of the above compound 15 was dissolved in 11 ml of methanol and then 1 ml of methylamine (30% methanol solution) was added dropwise thereto. After stirring overnight at room temperature, the crystalline precipitate was filtered off and recrystallized from ligroin to give 0.38 g of 5-methylamino-1,3-dimethylpyrimido[4,5-d]pyrimidine-2,4-dione (compound 16) in a 85% yield.

후처리

  1. filtrationthe crystalline precipitate was filtered off
  2. customrecrystallized from ligroin

출처 및 근거

ORD 기록
ord-8568507012d94042bb8051b5155f08e5
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886807

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