Ammonia → 5-Amino-7-(3-amino-3-methyl1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro4-oxoquinoline-3-carboxylic acid

HRID 477026노트

반응식

HRID 477026 반응식
[NH2:1][C:2]1([CH3:27])[CH2:6][CH2:5][N:4]([C:7]2[C:16]([F:17])=[C:15]3[C:10]([C:11](=[O:24])[C:12]([C:21]([OH:23])=[O:22])=[CH:13][N:14]3[CH:18]3[CH2:20][CH2:19]3)=[C:9](F)[C:8]=2[F:26])[CH2:3]1.[NH3:28]>>[NH2:28][C:9]1[C:8]([F:26])=[C:7]([N:4]2[CH2:5][CH2:6][C:2]([NH2:1])([CH3:27])[CH2:3]2)[C:16]([F:17])=[C:15]2[C:10]=1[C:11](=[O:24])[C:12]([C:21]([OH:23])=[O:22])=[CH:13][N:14]2[CH:18]1[CH2:19][CH2:20]1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 14304602HCID 14304602, 화합물

생성물 1

HCID 157293795-Amino-7-(3-amino-3-methyl1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro4-oxoquinoline-3-carboxylic acid

반응 조건

온도
100 °C

실험 절차

A mixture of 7-(3-amino-3-methyl-1-pyrrolidinyl)-1-cyclopropyl-5,6,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (150 mg) and 28% aqueous ammonia (15 ml) was heated at 100° C. for 48 hours in a sealed tube. The reaction mixture was evaporated to dryness under reduced pressure and water was added to the residue. The resulting crystals were treated in the same manner as described in Example 10 (1) to give 5-amino7-(3-amino-3-methyl-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (93 mg), m.p. 271°-273° C (decomp.).

후처리

  1. customThe reaction mixture was evaporated to dryness under reduced pressure and water
  2. additionwas added to the residue
  3. additionThe resulting crystals were treated in the same manner

출처 및 근거

ORD 기록
ord-21fb80f8f9384f09a84f946faa05538b
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886810

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