Methyl 5-(4-methoxy-3-nitrophenyl)-3-pyridinecarboxylate → HCID 19837271, 화합물
반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][CH:12]=[C:13]([CH:18]=2)[C:14]([O:16][CH3:17])=[O:15])=[CH:5][C:4]=1[N+:19]([O-])=O>C(OCC)(=O)C.[C].[Pd]>[NH2:19][C:4]1[CH:5]=[C:6]([C:9]2[CH:10]=[N:11][CH:12]=[C:13]([CH:18]=2)[C:14]([O:16][CH3:17])=[O:15])[CH:7]=[CH:8][C:3]=1[O:2][CH3:1]참가 물질
4
반응 조건
- 온도
- 50 °C
실험 절차
990 mg of the resulting nitro compound was dissolved in 60 ml of ethyl acetate, and 0.3 g of 10% palladium-carbon was added. The nitro compounds was thus catalytically reduced with stirring at 50° C. The catalyst was removed in a customary manner, and the resulting yellow crystals were recrystallized from methylene chloride-ether to give 723 mg (yield 81%) of methyl 5-(3-amino-4-methoxyphenyl)nicotinate as pale yellow needles having a melting point of 98° to 99° C.