Bromine → 2-Bromo-1-(2,4-dimethyl-1,3-thiazol-5-yl)ethan-1-one

HRID 477077

반응식

HRID 477077 반응식
[Br:1]Br.[CH3:3][C:4]1[S:5][C:6]([C:10](=[O:12])[CH3:11])=[C:7]([CH3:9])[N:8]=1>C(O)(=O)C>[CH3:3][C:4]1[S:5][C:6]([C:10](=[O:12])[CH2:11][Br:1])=[C:7]([CH3:9])[N:8]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 5208882,4-Dimethyl-5-acetylthiazole

생성물 1

HCID 126684222-Bromo-1-(2,4-dimethyl-1,3-thiazol-5-yl)ethan-1-one

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

A solution of 20.8 g (0.13 mol) of bromine in 50 ml of glacial acetic acid is slowly added dropwise to a solution of 20.2 g (0.13 mol) of 2,4-dimethyl-5-acetyl-thiazole in glacial acetic acid, heated to reflux. After 1 hour, the mixture is evaporated to dryness, the residue is dissolved in water, and the solution is neutralised with sodium carbonate solution. The mixture is then extracted several times with methylene chloride, and the organic phase is dried and concentrated. The oil which was obtained in this way was used for further reactions without further purification.

후처리

  1. temperatureheated to reflux
  2. customthe mixture is evaporated to dryness
  3. dissolutionthe residue is dissolved in water
  4. extractionThe mixture is then extracted several times with methylene chloride
  5. customthe organic phase is dried
  6. concentrationconcentrated
  7. customThe oil which was obtained in this way
  8. customwas used for further reactions without further purification

출처 및 근거

ORD 기록
ord-c100fbbbf50548f48e62e2bdcef297b7
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886814

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