Malonic Acid → 3-(5-Cyano-2-thiophenyl)-propenoic acid
반응식
[C:1]([C:3]1[S:7][C:6]([CH:8]=O)=[CH:5][CH:4]=1)#[N:2].C(O)(=O)[CH2:11][C:12]([OH:14])=[O:13]>N1C=CC=CC=1.N1CCCCC1>[C:1]([C:3]1[S:7][C:6]([CH:8]=[CH:11][C:12]([OH:14])=[O:13])=[CH:5][CH:4]=1)#[N:2]참가 물질
5
실험 절차
A stirred solution of 5-cyano-2-thiophene carboxaldehyde (3.3 g) and malonic acid (2.5 g) in pyridine (35 ml) and piperidine (0.7 ml) was heated under reflux for 2 hours adding further malonic acid (1.3 g) after 1 hour. The solution was evaporated and the residue was stirred with M hydrochloric acid solution (100 ml) to give a pale solid which was washed with water and dried, m.p. ca 260° C. (subliming).
후처리
- temperatureunder reflux for 2 hours
- customThe solution was evaporated
- customto give a pale solid which
- washwas washed with water
- customdried
출처 및 근거
- ORD 기록
- ord-5974a54b8de34cc1931a9ce2ebd93e8e
- 출처 데이터셋
- uspto-grants-1989_12
- 특허 번호
- US04886885
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