Malonic Acid → 3-(5-Cyano-2-thiophenyl)-propenoic acid

HRID 477171

반응식

HRID 477171 반응식
[C:1]([C:3]1[S:7][C:6]([CH:8]=O)=[CH:5][CH:4]=1)#[N:2].C(O)(=O)[CH2:11][C:12]([OH:14])=[O:13]>N1C=CC=CC=1.N1CCCCC1>[C:1]([C:3]1[S:7][C:6]([CH:8]=[CH:11][C:12]([OH:14])=[O:13])=[CH:5][CH:4]=1)#[N:2]

참가 물질

5

반응물 2

HCID 867Malonic Acid2회HCID 122800045-Formylthiophene-2-Carbonitrile

생성물 1

HCID 679354333-(5-Cyano-2-thiophenyl)-propenoic acid

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 8082Piperidine용매

실험 절차

A stirred solution of 5-cyano-2-thiophene carboxaldehyde (3.3 g) and malonic acid (2.5 g) in pyridine (35 ml) and piperidine (0.7 ml) was heated under reflux for 2 hours adding further malonic acid (1.3 g) after 1 hour. The solution was evaporated and the residue was stirred with M hydrochloric acid solution (100 ml) to give a pale solid which was washed with water and dried, m.p. ca 260° C. (subliming).

후처리

  1. temperatureunder reflux for 2 hours
  2. customThe solution was evaporated
  3. customto give a pale solid which
  4. washwas washed with water
  5. customdried

출처 및 근거

ORD 기록
ord-5974a54b8de34cc1931a9ce2ebd93e8e
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886885

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