참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-Chloro-2-(dimethoxymethyl)-1-nitrobenzene | HCID 3570093 | — |
| 반응물 | 4-Acetamidopiperidine dihydrochloride | HCID 11401105 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 2-Nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde dimethylacetal | HCID 19086863 | — |
반응 단계
12 Grams of 2-nitro-5-chlorobenzaldehyde dimethyl acetal, 16.3 g of 4-acetylaminopiperidine hydrochloride, 13.7 g of sodium carbonate and 13 ml of triethylamine in 150 ml of N-methylpyrrolidone solution were mixed together and reacted by heating at 120° C. for 12 hours with stirring under nitrogen gas stream. After the reaction was completed, the solvent was removed by evaporation and thus obtained residue was added with water and extracted with dichloromethane, then the extract was washed with water and with an aqueous solution saturated with sodium chloride, then dried with anhydrous sodium sulfate. The solvent was removed by evaporation and the residue thus obtained was added with diethyl ether, then the crystals formed were collected by filtration to yield 11.2 g of 2-nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde dimethylacetal.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04886809 |
|---|
| 출처 데이터셋 | uspto-grants-1989_12 |
|---|
| ORD ID | ord-67b3db273b304161b3597310c64abb49 |
|---|
| 출처 메모 | uspto-grants-1989_12 |
|---|
