Dichloromethane → N-(tert-butyl)-N'-[2-hydroxy-1-(3-nitrophenyl)ethyl]thiourea

HRID 47719

반응식

HRID 47719 반응식
[NH2:1][CH:2]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[CH:6]=1)[CH2:3][OH:4].ClCCl.[C:17]([N:21]=[C:22]=[S:23])([CH3:20])([CH3:19])[CH3:18]>C(O)C>[C:17]([NH:21][C:22]([NH:1][CH:2]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[CH:6]=1)[CH2:3][OH:4])=[S:23])([CH3:20])([CH3:19])[CH3:18]

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 11544tert-Butyl isothiocyanate2회HCID 157522992-Amino-2-(3-nitrophenyl)ethan-1-ol

생성물 1

HCID 22747831N-(tert-butyl)-N'-[2-hydroxy-1-(3-nitrophenyl)ethyl]thiourea

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The process is performed as in Example 2, starting with 5.1 g of 2-amino-2-(3-nitrophenyl)-1-ethanol in 170 cm3 of ethanol containing 85 cm3 of dichloromethane and 4.6 cm3 of tert-butyl isothiocyanate, at a temperature in the region of 20° C. for 3 days and then at a temperature in the region of 60° C. for 7 hours. After addition of a further 0.35 cm3 of tert-butyl isothiocyanate and 16 hours at a temperature in the region of 60° C., an identical work-up gives 5.7 g of N-(tert-butyl)-N′-[2-hydroxy-1-(3-nitrophenyl)ethyl]thiourea in the form of an ocher-colored solid melting at 162° C.

출처 및 근거

ORD 기록
ord-8aad5d416b254211b007e94300ebbd9a
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06699895B2

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