Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl isothiocyanate → N-(tert-butyl)-N'-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]thiourea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl isothiocyanate | HCID 11544 | — |
| 반응물 | phenylalaninol, (R)- | HCID 853475 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-(tert-butyl)-N'-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]thiourea | HCID 86584424 | 98.8% |
반응 단계
The process is performed as in Example 2, starting with 5 g of (R)-(+)2-amino-3-phenyl-1-propanol in 50 cm3 of ethanol and 5.7 g of tert-butyl isothiocyanate at a temperature in the region of 20° C. for 16 hours. After an identical work-up, 8.7 g of N-(tert-butyl)-N′-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]thiourea are obtained in the form of a white solid melting at 107° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06699895B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-787673440b6549b1a89c1c97caa345fe |
| 출처 메모 | uspto-grants-2004_03 |