Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium ethoxide → Ethyl 2-dimethylamino-6-(4-methoxyphenyl)-5-methylthio-6-oxo-2,4-hexadienoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | Ethyl 6-phenyl-6-oxo-5-methylthio-2-dimethylamino2,4-hexadienoate | HCID 44325574 | — |
| 반응물 | N-(dimethylamino-3-ethoxycarbonylpropenylidene)-N-methylmethanaminium tetrafluoroborate | HCID 86743575 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 2-dimethylamino-6-(4-methoxyphenyl)-5-methylthio-6-oxo-2,4-hexadienoate | HCID 53906391 | — |
반응 단계
The procedure is as in Example 4 for the preparation of ethyl 6-phenyl-6-oxo-5-methylthio-2-dimethylamino-2,4-hexadienoate, starting with N-(3-dimethylamino-3-ethoxycarbonylpropenylidene)-N-methylmethanaminium tetrafluoroborate (13.9 g), a 2M ethanolic solution of sodium ethylate (24.2 cc) and α-methylthio-4-methoxyacetophenone (9.5 g) in ethanol (97 cc). After purification on a silica column with a mixture of cyclohexane and ethyl acetate (50:50 by volume) as eluent, ethyl 2-dimethylamino-6-(4-methoxyphenyl)-5-methylthio-6-oxo-2,4-hexadienoate (6.1 g) is obtained, and is used in the crude state in the subsequent syntheses.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04886835 |
| 출처 데이터셋 | uspto-grants-1989_12 |
| ORD ID | ord-efbe6c2fac6041caab14f4400bf6e2e9 |
| 출처 메모 | uspto-grants-1989_12 |