Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium ethoxide → Ethyl 6-(3,4-dihydroxyphenyl)-2-dimethylamino-5-methylthio-6-oxo-2,4-hexadienoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | 3',4'-Dihydroxy-2-(methylthio)acetophenone | HCID 13718339 | — |
| 반응물 | Ethyl 6-phenyl-6-oxo-5-methylthio-2-dimethylamino2,4-hexadienoate | HCID 44325574 | — |
| 반응물 | N-(dimethylamino-3-ethoxycarbonylpropenylidene)-N-methylmethanaminium tetrafluoroborate | HCID 86743575 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 6-(3,4-dihydroxyphenyl)-2-dimethylamino-5-methylthio-6-oxo-2,4-hexadienoate | HCID 53865515 | 17.1% |
반응 단계
The procedure is as in Example 4 for the preparation of ethyl 6-phenyl-6-oxo-5-methylthio-2-dimethylamino-2,4-hexadienoate, starting with N-(3-dimethylamino-3-ethoxycarbonylpropenylidene)-N-methylmethanaminium tetrafluoroborate (11.4 g), a 2M ethanolic solution of sodium ethylate (60 cc) and 4-[2-(methylthio)acetyl]pyrocatechol (7.9 g) in ethanol (60 cc). After purification on a silica column with a mixture of cyclohexane and ethyl acetate (50:50 by volume) as eluent, ethyl 6-(3,4-dihydroxyphenyl)-2-dimethylamino-5-methylthio-6-oxo-2,4-hexadienoate (2.4 g), m.p. 144° C., is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04886835 |
| 출처 데이터셋 | uspto-grants-1989_12 |
| ORD ID | ord-0b9009d9704d420ea5d4e8232a849219 |
| 출처 메모 | uspto-grants-1989_12 |