Sodium ethoxide → Diethyl 2-dimethylamino-5-(4-phenylbenzylthio)-2,4-hexadienedioate

HRID 477333

반응식

HRID 477333 반응식
CN(C)C(=CC=C(C1C=CC=CC=1)C(OCC)=O)C(OCC)=S.F[B-](F)(F)F.[CH3:29][N:30]([CH3:42])[C:31]([C:37]([O:39][CH2:40][CH3:41])=[O:38])=[CH:32][CH:33]=[N+](C)C.CC[O-].[Na+].[C:47]1([C:53]2[CH:66]=[CH:65][C:56]([CH2:57][S:58][CH2:59][C:60]([O:62][CH2:63][CH3:64])=[O:61])=[CH:55][CH:54]=2)[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1>C(O)C>[CH3:29][N:30]([CH3:42])[C:31](=[CH:32][CH:33]=[C:59]([S:58][CH2:57][C:56]1[CH:55]=[CH:54][C:53]([C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)=[CH:66][CH:65]=1)[C:60]([O:62][CH2:63][CH3:64])=[O:61])[C:37]([O:39][CH2:40][CH3:41])=[O:38]

참가 물질

6

반응물 4

HCID 2723922Sodium ethoxideHCID 54328963Ethyl (4-phenylbenzylthio)acetateHCID 86743575N-(dimethylamino-3-ethoxycarbonylpropenylidene)-N-methylmethanaminium tetrafluoroborateHCID 86743580Diethyl 2-dimethylamino-5-phenylthio-2,4-hexadienedioate

생성물 1

HCID 53850243Diethyl 2-dimethylamino-5-(4-phenylbenzylthio)-2,4-hexadienedioate수율 68.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The procedure is as in Example 2 for the preparation of diethyl 2-dimethylamino-5-phenylthio-2,4-hexadienedioate, starting with N-(3-dimethylamino-3-ethoxycarbonylpropenylidene)-N-methylmethanaminium tetrafluoroborate (5.7 g), a 2M ethanolic solution of sodium ethylate (10 cc) and ethyl (4-phenylbenzylthio)acetate (5.7 g) in ethanol (50 cc). After purification by chromatography on a silica column with a mixture of cyclohexane and ethyl acetate (70:30 by volume) as eluent, diethyl 2-dimethylamino-5-(4-phenylbenzylthio)-2,4-hexadienedioate (6 g) is obtained in the form of a yellow oil, and is used in the crude state in the subsequent syntheses.

후처리

  1. customAfter purification by chromatography on a silica column
  2. additionwith a mixture of cyclohexane and ethyl acetate (70:30 by volume) as eluent

출처 및 근거

ORD 기록
ord-bbd425d9d9304318b05b5d864d20db65
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04886835

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