2,4-Di-tert-butylphenol → Cyclohexanone, 2,4-bis(1,1-dimethylethyl)-

HRID 477424

반응식

HRID 477424 반응식
[C:1]([C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:8]=[CH:7][C:6]=1[OH:15])([CH3:4])([CH3:3])[CH3:2].[H][H]>[C].[Pd]>[C:1]([CH:5]1[CH2:10][CH:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH2:8][CH2:7][C:6]1=[O:15])([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 73112,4-Di-tert-butylphenolHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 114442Cyclohexanone, 2,4-bis(1,1-dimethylethyl)-수율 71.3%

시약·촉매·용매 1

HCID 178418390HCID 178418390, 화합물촉매

실험 절차

300 g of 2,4-di-tert-butylphenol and 3.0 g of 5% palladium-carbon catalyst were introduced into a 500 ml autoclave and stirred therein at a reaction temperature of 180° C. under a hydrogen pressure of 20 kg/cm2. After approximately ten hours, the absorption of the theoretical amount (2.9 moles) of hydrogen was confirmed. Then the reaction mixture was cooled to room temperature and the catalyst was filtered off. 218 g of the crude 2,4-di-tert-butylcyclohexanone thus obtained was distilled under reduced pressure in a Helipack packing column of a number of theoretical plates of 5 to give 245 g of a colorless and transparent 2,4-di-tert-butylcyclohexanone (I) fraction (b.p.: 93° to 94° C./3 mm Hg). It was confirmed by gas chromatography that this product was a mixture of cisisomer (I-A) and trans-isomer (I-B) at a ratio of 83:17. The physical properties of this product were as follows:

후처리

  1. customat a reaction temperature of 180° C.
  2. waitAfter approximately ten hours
  3. filtrationthe catalyst was filtered off

출처 및 근거

ORD 기록
ord-0792d2a5cd53401794f6cacc7953f916
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04888323

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