Thiazole → HCID 70392285, 화합물

반응식

[CH2:1]([CH:7]1[CH2:11][CH:10]=[CH:9][O:8]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[Cl:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19].[S:20]1[CH:24]=[CH:23][N:22]=[CH:21]1>>[Cl-:12].[CH2:1]([CH:7]1[CH2:11][CH2:10][CH:9]([O:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][C:21]2[S:20][CH:24]=[CH:23][NH+:22]=2)[O:8]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6]

참가 물질

반응물 3

HCID 9256Thiazole

HCID 748286-Chloro-1-hexanol

HCID 135384132-Hexyl-2,3-dihydrofuran

생성물 1

HCID 70392285HCID 70392285, 화합물

실험 절차

Analogous to example 9 but starting from 2-hexyl-2,3-dihydrofuran and 6-chlorohexanol. Substitution of the chloro atom was performed with thiazole instead of pyridine in the same conditions but on a mixture of cis+trans isomers leading to the title compound as an highly hygroscopic compound.

출처 및 근거

ORD 기록: ord-0db2840020c14e75a9564c7bd69b8185
출처 데이터셋: uspto-grants-1989_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04888337

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