Water → HCID 19872277, 화합물

HRID 477748노트

반응식

HRID 477748 반응식
[CH2:1]([S:8][C:9]1[N:13]=[C:12]([OH:14])[N:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.F[B-](F)(F)F.[CH3:26][O+](C)C.O>ClCCl>[CH2:1]([S:8][C:9]1[N:13]=[C:12]([O:14][CH3:26])[N:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 2735153Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1)HCID 178518539HCID 178518539, 화합물

생성물 1

HCID 19872277HCID 19872277, 화합물수율 51.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-Benzylthio-5-hydroxy-1-phenyl-1,2,4-triazole (15 g) in dichloromethane (60 ml) was treated with trimethyloxonium tetrafluoroborate (15.7 g) and allowed to stand for 18 hours at room temperature. The reaction mixture was poured into water (200 ml) and the aqueous layer was washed with dichloromethane (2×100 ml). The dried organic layer was evaporated and then purified by column chromatography (silica/petroleum ether:ether), to give 8.1 g of the desired product.

후처리

  1. washthe aqueous layer was washed with dichloromethane (2×100 ml)
  2. customThe dried organic layer was evaporated
  3. custompurified by column chromatography (silica/petroleum ether:ether)

출처 및 근거

ORD 기록
ord-0add69fccb2c4325b368ced7bf65ca27
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04889553

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