1,2-Diiodoethane → 2-(4-Trifluoromethylphenyl)-5-iodothiazole

HRID 477898

반응식

HRID 477898 반응식
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:10][CH:11]=[CH:12][N:13]=2)=[CH:5][CH:4]=1.C([Li])CCC.[I:21]CCI>CCCCCC.C(OCC)C>[F:15][C:2]([F:1])([F:14])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[S:10][C:11]([I:21])=[CH:12][N:13]=2)=[CH:7][CH:8]=1

참가 물질

6

반응물 3

HCID 122241,2-DiiodoethaneHCID 146019692-(4-(Trifluoromethyl)phenyl)thiazoleHCID 178418339Butyllithium

생성물 1

HCID 146019702-(4-Trifluoromethylphenyl)-5-iodothiazole수율 46.5%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8058Hexane용매

실험 절차

In a manner similar to Step C of Example 1, the reaction of 5.45 grams (0.0238 mole) of 2-(4-trifluoromethylphenyl)thiazole, 9.5 ml of a 2.5 M solution of n-butyllithium in hexane, and 6.71 grams (0.0238 mole) of 1,2-diiodoethane in 40 ml of diethyl ether produced 3.93 grams of 2-(4-trifluoromethylphenyl)-5-iodothiazole as a solid.

출처 및 근거

ORD 기록
ord-952bda2a830d45e2b3066c627e9e143c
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04889867

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