Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Butyn-2-one → 10-acetyl-4,5-dihydro-8-(m-fluorophenyl)7H-thieno[2,3-a]quinolizin-7-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Butyn-2-one | HCID 15018 | — |
| 반응물 | HCID 14770024 | HCID 14770024 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 10-acetyl-4,5-dihydro-8-(m-fluorophenyl)7H-thieno[2,3-a]quinolizin-7-one | HCID 19020483 | — |
반응 단계
A solution of 0.303 g of 5,6-dihydro-3-hydroxy-2-(m-fluorophenyl)-thiazolo-[3,2-a]thieno[2,3-c]pyridinium hydroxide (internal salt) and 0.145 ml of 3-butyn-2-one in 5 ml of toluene was heated under reflux for 1 hour. The solvent is evaporated in vacuo and the residue is chromatographed over silica gel with toluene/ethyl acetate (1:1). After recrystallization from ethanol, there was obtained 10-acetyl-4,5-dihydro-8-(m-fluorophenyl)-7H-thieno[2,3-a]quinolizin-7-one of m.p. 109°-110°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04889848 |
| 출처 데이터셋 | uspto-grants-1989_12 |
| ORD ID | ord-5c5089c2827e4d309a6486d40cd3740f |
| 출처 메모 | uspto-grants-1989_12 |