Thionyl Chloride → HCID 178509760, 화합물

HRID 477971노트

반응식

HRID 477971 반응식
C([NH:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([CH:14](O)[CH2:15][CH2:16][CH2:17][C:18]2[N:19]=[CH:20][N:21]([Si](C)(C)C)[CH:22]=2)=[CH:10][CH:9]=1)=O)(C)(C)C.S(Cl)([Cl:30])=O>>[Cl:30][CH:14]([C:11]1[CH:12]=[CH:13][C:8]([C:6]#[N:5])=[CH:9][CH:10]=1)[CH2:15][CH2:16][CH2:17][C:18]1[N:19]=[CH:20][NH:21][CH:22]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 199304194-[4-(p-tert-Butylaminocarbonylphenyl)-4-hydroxy-n-butyl]-1-trimethylsilylimidazole

생성물 1

HCID 178509760HCID 178509760, 화합물

실험 절차

A solution of 4.5 g of 4-[4-(p-tert-butylaminocarbonylphenyl)-4-hydroxy-n-butyl]-1-trimethylsilylimidazole in 50 ml of thionyl chloride is refluxed for 1 h, cooled and evaporated. The residue is partitioned between methylene chloride and aqueous sodium bicarbonate solution. The organic phase is separated, dried over sodium sulfate and evaporated to yield the title compound (c).

후처리

  1. temperaturecooled
  2. customevaporated
  3. customThe residue is partitioned between methylene chloride and aqueous sodium bicarbonate solution
  4. customThe organic phase is separated
  5. dry with materialdried over sodium sulfate
  6. customevaporated

출처 및 근거

ORD 기록
ord-5fbd31894475459982e5655955531d5c
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04889861

반응 노트

불러오는 중…