5-(p-Hydroxymethylphenyl)imidazo[1,5-a]pyridine → 5-(p-Formylphenyl)-imidazo[1,5-a]pyridine

HRID 477999노트

반응식

HRID 477999 반응식
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:14]3[CH:15]=[N:16][CH:17]=[C:13]3[CH:12]=[CH:11][CH:10]=2)=[CH:5][CH:4]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH:2]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:14]3[CH:15]=[N:16][CH:17]=[C:13]3[CH:12]=[CH:11][CH:10]=2)=[CH:7][CH:8]=1)=[O:1]

참가 물질

4

반응물 1

HCID 136494325-(p-Hydroxymethylphenyl)imidazo[1,5-a]pyridine

생성물 1

HCID 136494335-(p-Formylphenyl)-imidazo[1,5-a]pyridine

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매2회HCID 6344Dichloromethane용매

실험 절차

A solution of 5-(p-hydroxymethylphenyl)imidazo[1,5-a]-pyridine (0.52 g) in 10 ml of methylene chloride is refluxed with 5.2 g of activated manganese dioxide for 24 h. An additional 5.2 g of manganese dioxide is added and the reaction mixture is refluxed an additional 6 h, filtered, and the solvent is evaporated to yield 5-(p-formylphenyl)-imidazo[1,5-a]pyridine, m.p. 144°-146°.

후처리

  1. temperaturethe reaction mixture is refluxed an additional 6 h
  2. filtrationfiltered
  3. customthe solvent is evaporated

출처 및 근거

ORD 기록
ord-fee8a96e01d24cfebf0b48c9d739c0c6
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04889861

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