Methyl 3-amino-2-thiophenecarboxylate → HCID 178437764, 화합물

HRID 478065

반응식

HRID 478065 반응식
[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([O:9]C)=O.[C:11](N)(=[NH:14])[CH2:12][CH3:13]>>[CH2:12]([C:11]1[N:14]=[C:7]([OH:9])[C:3]2[S:4][CH:5]=[CH:6][C:2]=2[N:1]=1)[CH3:13]

참가 물질

3

반응물 2

HCID 89652Methyl 3-amino-2-thiophenecarboxylateHCID 415117Propionamidine hydrochloride

생성물 1

HCID 178437764HCID 178437764, 화합물수율 12.5%

반응 조건

온도
60 °C

실험 절차

Methyl 3-amino-2-thiophenecarboxylate (4.67 g,) and propionamidine (3 g,) were combined and heated in an oil both for 1/2 hour at 60° C.; 1/2 hour at 80° C.; 1/2 hour at 100° C. and finally for 4 hours at 120° C. The mixture was cooled, triturated with ether, filtered and washed with ether to obtain 0.67 g of the product; m.p. 233°-237° C.

후처리

  1. custom1/2 hour
  2. customat 80° C.
  3. temperatureThe mixture was cooled
  4. customtriturated with ether
  5. filtrationfiltered
  6. washwashed with ether

출처 및 근거

ORD 기록
ord-7f65ec5769b040989312ff30ea907ac2
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04889856

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