Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Heptanoic Acid → Heptanoic acid [2-(4-nitro-phenyl)-ethyl]-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Heptanoic Acid | HCID 8094 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Nitrophenethylamine | HCID 95153 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Heptanoic acid [2-(4-nitro-phenyl)-ethyl]-amide | HCID 86586370 | 81.3% |
반응 단계
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (3.86 g, 20.1 mmol) and heptanoic acid (2.38 mL, 16.8 mmol) were added sequentially to a solution of 4-nitrophenethylamine (3.40 g, 16.8 mmol), triethylamine (2.81 mL, 20.1 mmol) and methylene chloride (25 mL). After stirring 18 h at ambient temperature, the reaction mixture was diluted with ethyl acetate; washed sequentially with water, 1N aqueous hydrochloric acid, water, saturated aqueous sodium bicarbonate and saturated aqueous sodium chloride; dried over anhydrous sodium sulfate; filtered and concentrated under reduced pressure to provide 3.80 g (81%) of heptanoic acid [2-(4-nitro-phenyl)-ethyl]-amide as an off-white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06699904B2 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-a111074eabfd4a1fb8dcd2b34b409831 |
| 출처 메모 | uspto-grants-2004_03 |