Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Bromo-4-fluorobenzaldehyde → methyl 4-(3-bromo-4-fluorophenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Bromo-4-fluorobenzaldehyde | HCID 173604 | — |
| 반응물 | 2H-pyran-3,5(4H,6H)-dione | HCID 325287 | — |
| 반응물 | Methyl 3-aminocrotonate | HCID 643918 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | methyl 4-(3-bromo-4-fluorophenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate | HCID 11257964 | 50.5% |
반응 단계
A mixture of tetrahydropyran-3,5-dione (Terasawa, J. Org. Chem. (1977), 42, 1163-1169) (1.4 g, 12 mmol), 3-bromo-4-fluorobenzaldehyde (3.0 g, 15 mmol), methyl 3-aminocrotonate (1.4 g, 12 mmol) and ethyl alcohol (10 mL) was processed as described in Example 2A. Purification by flash chromatography over silica gel (1% then 2% and then 5% methyl alcohol/methylene chloride) provided the title compound (2.4 g) as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06642222B2 |
| 출처 데이터셋 | uspto-grants-2003_11 |
| ORD ID | ord-6f069885456a488c9abd175de1e5d856 |
| 출처 메모 | uspto-grants-2003_11 |