Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2H-pyran-3,5(4H,6H)-dione → methyl 4-(4-fluoro-3-iodophenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2H-pyran-3,5(4H,6H)-dione | HCID 325287 | — |
| 반응물 | Methyl 3-aminocrotonate | HCID 643918 | — |
| 반응물 | 4-Fluoro-3-iodobenzaldehyde | HCID 10308073 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | methyl 4-(4-fluoro-3-iodophenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate | HCID 18000962 | 45.1% |
반응 단계
The product from Example 11B (0.34 g, 3.0 mmol), the product from Example 30C (0.74 g, 3.0 mmol) and methyl 3-aminocrotonate (0.35 g, 3.0 mmol) in methanol (8 mL) were processed as described in Example 68A to provide the title compound (0.60 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06642222B2 |
| 출처 데이터셋 | uspto-grants-2003_11 |
| ORD ID | ord-30fc3e751320499c97cc9a2a6da98ec3 |
| 출처 메모 | uspto-grants-2003_11 |