2H-pyran-3,5(4H,6H)-dione → methyl 4-(3,4-dibromophenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate

HRID 478300

반응식

HRID 478300 반응식
[O:1]1[CH2:6][C:5](=O)[CH2:4][C:3](=[O:8])[CH2:2]1.[Br:9][C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][C:17]=1[Br:18])[CH:13]=O.[NH2:19]/[C:20](/[CH3:26])=[CH:21]\[C:22]([O:24][CH3:25])=[O:23]>C(O)C>[Br:9][C:10]1[CH:11]=[C:12]([CH:13]2[C:21]([C:22]([O:24][CH3:25])=[O:23])=[C:20]([CH3:26])[NH:19][C:5]3[CH2:6][O:1][CH2:2][C:3](=[O:8])[C:4]2=3)[CH:15]=[CH:16][C:17]=1[Br:18]

참가 물질

5

반응물 3

HCID 3252872H-pyran-3,5(4H,6H)-dioneHCID 6220533,4-DibromobenzaldehydeHCID 643918Methyl 3-aminocrotonate

생성물 1

HCID 18001000methyl 4-(3,4-dibromophenyl)-2-methyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate수율 65.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The product from Example 11B (0.17 g, 1.5 mmol), the product from 3,4-dibromobenzaldehyde (0.53 g, 2.0 mmol) and methyl 3-aminocrotonate (0.15 g, 1.3 mmol) in ethanol (8 mL) were heated at 80° C. in a sealed tube for 60 hours and then cooled to ambient temperature. The mixture was filtered and the filter cake was washed with ethanol and dried to provide the title compound (0.39 g).

후처리

  1. filtrationThe mixture was filtered
  2. washthe filter cake was washed with ethanol
  3. customdried

출처 및 근거

ORD 기록
ord-08abae15238d4a958673daa9e80be9a5
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06642222B2

연결된 노트

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