Ethanol → 5-ethoxy-2-methyl-2H-pyran-3(6H)-one

HRID 478308노트

반응식

HRID 478308 반응식
[CH3:1][CH:2]1[C:7](=[O:8])[CH2:6][C:5](=[O:9])[CH2:4][O:3]1.[CH2:10](O)[CH3:11]>S(=O)(=O)(O)O>[CH2:10]([O:9][C:5]1[CH2:4][O:3][CH:2]([CH3:1])[C:7](=[O:8])[CH:6]=1)[CH3:11]

참가 물질

4

반응물 2

HCID 702EthanolHCID 234974742-methyl-2H-pyran-3,5(4H,6H)-dione

생성물 1

HCID 180010055-ethoxy-2-methyl-2H-pyran-3(6H)-one

시약·촉매·용매 1

HCID 1118Sulfuric Acid촉매

실험 절차

The product from Example 84C (3.0 g, 23 mmol) was dissolved in ethanol (50 mL), treated with concentrated sulfuric acid (5 drops), heated to reflux for 3 hours and concentrated. The residue was purified by chromatography eluting with 10:1 and then 5:1 and then 2:1 hexane:ethyl acetate to provide the title compound as the faster moving isomer.

후처리

  1. temperatureheated
  2. temperatureto reflux for 3 hours
  3. concentrationconcentrated
  4. customThe residue was purified by chromatography
  5. washeluting with 10:1

출처 및 근거

ORD 기록
ord-13a9e2ec99674901be2c87a3f05fe087
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06642222B2

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