Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Bromo-4-fluorobenzaldehyde → ethyl 4-(3-bromo-4-fluorophenyl)-5-oxo-2-propyl-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Bromo-4-fluorobenzaldehyde | HCID 173604 | — |
| 반응물 | 2H-pyran-3,5(4H,6H)-dione | HCID 325287 | — |
| 반응물 | ethyl (2E)-3-amino-2-hexenoate | HCID 10986503 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | ethyl 4-(3-bromo-4-fluorophenyl)-5-oxo-2-propyl-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylate | HCID 18000997 | 88.2% |
반응 단계
The product from Example 95A (0.083 g, 0.52 mmol), the product from Example 11B (0.050 g, 0.44 mmol) and 3-bromo-4-fluorobenzaldehyde (0.116 g, 0.57 mmol) in ethanol (1 mL) were heated to 80 C. for 16 hours in a sealed tube, cooled to ambient temperature and concentrated to dryness. The residue was purified on silica gel eluting with 2% methanol in dichloromethane to provide the title compound (0.17 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06642222B2 |
| 출처 데이터셋 | uspto-grants-2003_11 |
| ORD ID | ord-53a2bef521b4435aa8bc35dcf5e41010 |
| 출처 메모 | uspto-grants-2003_11 |